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Blocking Notch-Sign...
Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke
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- Santopolo, Giuseppe (author)
- Karolinska Institutet,Karolinska Institute
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- Magnusson, Jens P. (author)
- Karolinska Institutet,Karolinska Institute
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- Lindvall, Olle (author)
- Lund University,Lunds universitet,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Lund University Research Groups,Skåne University Hospital
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- Kokaia, Zaal (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cells & Restorative Neurology,Forskargrupper vid Lunds universitet,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine,Lund University Research Groups,Skåne University Hospital
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- Frisén, Jonas (author)
- Karolinska Institutet,Karolinska Institute
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(creator_code:org_t)
- 2020-07-20
- 2020
- English.
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In: Cells. - : MDPI AG. - 2073-4409. ; 9:7
- Related links:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Subject headings
Close
- Stroke triggers neurogenesis in the striatum in mice, with new neurons deriving in part from the nearby subventricular zone and in part from parenchymal astrocytes. The initiation of neurogenesis by astrocytes within the striatum is triggered by reduced Notch-signaling, and blocking this signaling pathway by deletion of the gene encoding the obligate Notch coactivator Rbpj is sufficient to activate neurogenesis by striatal astrocytes in the absence of an injury. Here we report that blocking Notch-signaling in stroke increases the neurogenic response to stroke 3.5-fold in mice. Deletion of Rbpj results in the recruitment of a larger number of parenchymal astrocytes to neurogenesis and over larger areas of the striatum. These data suggest inhibition of Notch-signaling as a potential translational strategy to promote neuronal regeneration after stroke.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- astrocyte
- neurogenesis
- stem cell
- striatum
- stroke
Publication and Content Type
- art (subject category)
- ref (subject category)
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